In the normal situation, a negative feedback loop(s) exists to control cellular division. As such, we would expect to see pathway inactivation to enable controlled cell proliferation. However, in terms of the cancer cell scope exists for the RAS protein to become mutated, which enables hyperactivated cell division. Here, the cell no longer responds to negative feedback signals and therefore can no longer be “switched off”. This inherent hyperactivation causes increased proliferation and ultimately neoplasm presentation.